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Marijuana use can lead to the development of problem use, known as a marijuana use disorder, which takes the form of addiction in severe cases ... Marijuana use disorders are often associated with dependence, which occurs when the brain adapts to large amounts of the drug by reducing production of and sensitivity to its own endocannabinoid neurotransmitter... Marijuana use disorder becomes addiction when the person cannot stop using the drug even though it interferes with many aspects of his or her life ...

Estimates of the number of people addicted to marijuana are controversial, in part because epidemiological studies of substance use often use dependence as a proxy for addiction even though it is possible to be dependent without being addicted. Those studies suggest that 9 percent of people who use marijuana will become dependent on it, rising to about 17 percent in those who start using in their teens." (NIH National Institute on Drug Abuse)

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